Project

Study of NeuroHIV Cure Consortium (Protocols: RV254, RV397, RV398)

Study of NeuroHIV Cure Consortium (Protocols: RV254, RV397, RV398)

Principal Investigator: Paul, Robert
Funder: National Institute of Health
Official Title: Study of NeuroHIV Cure Consortium (Protocols: RV254, RV397, RV398)

Study of NeuroHIV Cure Constortium (Protocols: RV254, RV397, RV398)

RV 254 is an observational study in Thailand which screens 30,000 subjects each year with a target of capturing 30 acute HIV infected (AHI) subjects per year. Subjects undergo neurological and neuropsychological evaluation at baseline and annually. Blood, plasma, and CSF specimens are captured and stored for virological and immunological assays, and subjects undergo MRI. RV 397 is a treatment interruption study in Thailand that will test the efficacy of vaccine administration during analytical treatment interruption (ATI). The study will enroll 24 HIV-infected subjects who initiated antiretroviral therapy (ART) within the first few weeks of infection and successfully suppressed viral load with ART for at least 2 years. RV 398 is a protocol designed to study the co-administration of a vaccine and ART in subjects in Thailand, Kenya, Uganda and Tanzania. Each arm of this study will have 8 subjects for a total sample size of 24 subjects.

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