Project

Neuromarkers of Age-Related Cognitive Decline

Neuromarkers of Age-Related Cognitive Decline

Principal Investigator: Paul, Robert
July 1, 2007 - June 30, 2010
Funder: National Institute of Aging
Official Title: Neuromarkers of Age-Related Cognitive Decline

This study will investigate relationships between novel neuroimaging markers based on diffusion tensor imaging (DTI) fiber tracking models, genetic polymorphisms of vascular disease and inflammation, and age-related cognitive decline in healthy individuals. Recent studies, including data from our lab, indicate that the integrity of the subcortical white matter as measured by DTI and subcortical hyperintensities on structural MRI are important correlates of age-related cognitive differences. Cortical brain volume changes also account for some variance in cognitive function among the elderly, however our data suggest that alterations in the subcortical white matter more strongly correlate with cognitive status. Newly recruited individuals will be followed longitudinally to examine the evolution and progression of white matter and cognitive abnormalities in the context of genetic risk factors. This study will be the first to integrate these approaches to examine a model of age-related cognitive decline implicating the subcortical white matter.

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