Project

Neurodevelopment and Imaging Among HIV-infected Children from the PREDICT Study

Neurodevelopment and Imaging Among HIV-infected Children from the PREDICT Study

Website: https://eSbirt.org
Principal Investigator: Paul, Robert
June 1, 2010 - May 30, 2013
Funder: National Institute of Mental Health
Official Title: Neurodevelopment and Imaging Among HIV-infected Children from the PREDICT Study

Treatment guidelines for children with HIV/AIDS are often based on findings in adults and seldom assembled from studies employing a randomized design. Many children with HIV/AIDS live in resource-limited areas. This rationale led the NIH to initiate the PREDICT study underway in Thailand and Cambodia. PREDICT uses a randomized design to determine the optimal timing of antiretroviral initiation in children. International guidelines for antiretroviral therapy (ART) initiation in children older than 12 months continue to recommend deferring therapy until symptomatic disease or immune compromise occurs, despite studies in younger infants (CHER trial) identifying a benefit for early treatment. This project will add robust neurodevelopmental and imaging outcomes to PREDICT. This work will extend our current limited evaluation of neurodevelopmental outcomes to determine if differences in long-term neuropsychological and neurological outcomes exist in relation to deferring antiretroviral therapy. Since microencephaly is a common manifestation of HIV in children, volumetric analyses may be most informative.

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