Project

Improving Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV

Improving Adherence to Highly Active Antiretroviral Therapy (HAART) in HIV

Website: https://eSbirt.org
Principal Investigator: Paul, Robert
June 1, 2002 - May 31, 2007
Funder: National Institute of Mental Health
Official Title: Improving Adherence to HARRT in HIV

A total of 125 HIV-positive individuals will be monitored for adherence during a four-week baseline period. Immunological status, psychosocial variables associated with behavior change, and cognitive function will be examined at baseline. One group will receive standard clinical care (SC). The second group will receive standard care and a pre-programmed wristwatch that will deliver a mnemonic aid (MA) to facilitate HAART dosing. Immunological status, psychosocial variables, cognitive function, and adherence will be re-examined after six months and again one month after the end of the trial. Analyses will determine the efficacy of the MA to support adherence to HAART. Regression analyses will be conducted to determine the degree to which adherence is associated with CD4/CD8 cell count, plasma viral load, and cognitive function. The relationship between psychosocial factors associated with behavior change and adherence will be examined in both treatment groups.

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