Project

Functional Neuroimaging of Cognitive Impairment in HIV-HCV Co-infection

Functional Neuroimaging of Cognitive Impairment in HIV-HCV Co-infection

Principal Investigator: Paul, Robert
September 1, 2006 - August 31, 2007
Funder: National Institute of Drug Abuse
Official Title: Functional Neuroimaging of Cognitive Impairment in HIV-HCV Co-Infection

Recent preliminary studies, including data from our lab, indicate that HIV-HCV co-infection is associated with greater neurocognitive compromise than either disease alone. Studies conducted to date have not fully determined the mechanisms underlying the potentially synergistic effect of co-infection. Further, the neurofunctional underpinnings of these effects have not been identified using functional or structural neuroimaging. Recent data from our laboratory identified strong relationships between markers of hepatic disease and cognitive outcome as well as relationships between neuroimaging abnormalities and cognitive function in co-infected individuals. The present study will extend these pilot data and examine CNS abnormalities in co-infected individuals using laboratory, neuroimaging and neurocognitive data. We recruited two groups of active injection drug abusers including: 1) 30 HIV mono-infected patients, and 2) 30 HIV-HCV co-infected patients. All individuals will undergo laboratory testing including assessment of hepatic disease and HIV disease in the periphery, functional MRI, structural neuroimaging and neurocognitive assessment.

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