Project

Cognitive Effects of Bariatric Surgery

Cognitive Effects of Bariatric Surgery

Principal Investigator: Paul, Robert
September 1, 2006 - August 31, 2009
Funder: National Institute of Heart, Lung and Blood
Official Title: Cognitive Effects of Bariatric Surgery

There is growing evidence that obesity is associated with adverse neurocognitive outcome. Recent studies demonstrate that elevated body mass index (BMI) is an independent risk factor for Alzheimer’s disease, structural brain abnormalities, and cognitive dysfunction in older adults. Preliminary work from our lab extends these findings and shows structural brain differences and cognitive dysfunction also exist in obese young and middle-aged adults. Bariatric surgery is increasingly viewed as an effective intervention for morbid obesity. Post-operative nutritional deficiencies are common and can adversely impact cognitive performance. However, substantial weight loss resolves or improves many medical conditions with reversible cognitive effects, suggesting bariatric surgery may provide cognitive benefits. No study to date has examined the cognitive effects of bariatric surgery. We hypothesize that the substantial weight loss following bariatric surgery will be associated with improved cognitive performance.

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