Active: Active Degree: PhD, ABCN Academic Title: Professor Institute Title: Director Email:firstname.lastname@example.org Office Phone: 314-516-8403 Fax Phone: 314-516-8405
Dr. Paul’s research program is focused on mechanisms of brain dysfunction in health conditions that primarily impact brain structures located deep beneath the surface of the cerebral cortex.
Dr. Paul’s research team has developed specific expertise in human immune deficiency syndrome (HIV), subcortical stroke, and early life trauma as three conditions that impact the integrity of deep brain structures including the white matter, basal ganglia, and limbic structures. Neuropsychological methods and neuroimaging techniques are primary research methods applied by Dr. Paul’s team to define behavioral and anatomical signatures of brain dysfunction in these conditions. Dr. Paul has a special interest in the application of these methods in resource-limited environments and he has active research programs in South Africa, Africa, Thailand, Vietnam, and Cambodia. He is a member of the HIV Cure Consortium and he works closely with collaborators at University of California San Francisco, Brown, Yale, and Washington University.
This study will assess cardiovascular and neurocognitive functions, along with brain MRI to determine the effect of specific vascular disturbances on brain structure and function. It will also determine the effect of that such impairments have on CR outcome, quality of life, and longer-term health status of the elderly.
This study will provide important information regarding: 1) the cognitive effects of bariatric surgery; 2) possible mechanisms for these effects; and 3) the contribution of cognitive performance to short- and long-term outcome of bariatric surgery.
This study will examine cognitive function in HIV-infected women who abuse cocaine in addition to other substances, women that do not abuse cocaine but do abuse other substances, and a healthy control group. Results from the study will extend our understanding of the factors that affect cognition in HIV.
Group comparisons and latent variable modeling will be conducted to examine relationships between the neuroimaging indices, genetic polymorphisms, and differences in cognitive function in older healthy adults. This study will be the first to integrate these approaches to examine a model of age-related cognitive decline implicating the subcortical white matter.