Active: Active Degree: PhD, ABCN Academic Title: Professor Institute Title: Director Email:email@example.com Office Phone: 314-516-8403 Fax Phone: 314-516-8405
Dr. Paul’s research program is focused on mechanisms of brain dysfunction in health conditions that primarily impact brain structures located deep beneath the surface of the cerebral cortex.
Dr. Paul’s research team has developed specific expertise in human immune deficiency syndrome (HIV), subcortical stroke, and early life trauma as three conditions that impact the integrity of deep brain structures including the white matter, basal ganglia, and limbic structures. Neuropsychological methods and neuroimaging techniques are primary research methods applied by Dr. Paul’s team to define behavioral and anatomical signatures of brain dysfunction in these conditions. Dr. Paul has a special interest in the application of these methods in resource-limited environments and he has active research programs in South Africa, Africa, Thailand, Vietnam, and Cambodia. He is a member of the HIV Cure Consortium and he works closely with collaborators at University of California San Francisco, Brown, Yale, and Washington University.
This study will provide valuable data to facilitate our understanding of the relationship between physical frailty and neurocognitive impairment in older HIV+ participants and may help future adjunctive therapies.
This project assists nurses and clinicians in deciding the appropriate timing for initiating highly active antiretroviral therapy (HAART) and helps them evaluate the efficacy of tailored adjunctive neuroprotective therapies.
The goal of this project is to examine the neurovirulence of clade C HIV. The study utilizes diffusion tensor imaging, viral laboratory markers, and neuropsychological function to characterize the relevance of the Tat protein defect in clade C HIV.
The NeuroHIV Cure Consortium is a research collaboration that operates numerous neurological research studies related to acute HIV infection and cure strategies. The NeuroHIV Cure Consortium is primarily responsible for developing studies focused on HIV eradication and reservoirs in the central nervous system in partnership with these groundbreaking studies.